http://www.lung-cancer-blog.com/blogs/lung-cancer-blog.html Lung cancer blog From Lung cancer blog en-us http://www.lung-cancer-blog.com/images/blogs/lung-cancer-blog-78210.jpg http://www.lung-cancer-blog.com/blogs/lung-cancer-blog.html 100111 http://www.lung-cancer-blog.com/blogs/permalinks/1-2010/childhood-harms-can-lead-to-lung-cancer.html Adverse events in childhood have been associated with an increase in the likelihood of developing lung cancer in later life. Scientists writing in the open access journal BMC Public Health describe how the link is partly explained by raised rates of cigarette smoking in victims of childhood trauma, but note that other factors may also be to blame........ http://www.lung-cancer-blog.com/blogs/permalinks/1-2010/lung-cancer-mystery.html The volcanic eruptions thought responsible for Earth's largest mass extinction which killed more than 70 percent of plants and animals 250 million years ago is still taking lives today. That's the conclusion of a newly released study showing, for the first time, that the high silica content of coal in one region of China appears to be interacting with volatile substances in the coal to cause uncommonly high rates of lung cancer. The study, which helps solve this cancer mystery, appears in ACS' Environmental Science and Technology, a semi-monthly publication........ http://www.lung-cancer-blog.com/blogs/permalinks/12-2009/destruction-of-a-tumor-suppressor.html Scientists from the Indiana University School of Medicine and his colleagues at the University of Texas Southwestern and Case Western University have determined how the protein Mdm2, which is elevated in late-stage cancers, disables genes that suppress the growth of tumors. The finding may lead to the development of new drugs for late stage breast cancer and other difficult to treat malignancies........ http://www.lung-cancer-blog.com/blogs/permalinks/12-2009/lung-cancer-overall-survival-rates-improving.html Research released in the December 2009 issue of the Journal of Thoracic Oncology sought to determine whether the survival improvement among patients with metastatic lung cancer has improved over the last two decades as reported in controlled clinical trials. Scientists performed an analysis of over 100,000 patients with stage IV non-small cell lung cancer (NSCLC) identified through the SEER database to evaluate trends in survival between 1990 and 2005 to assess the true impact of recent medical advances on these patients. Daniel Morgensztern, MD of the Washington University School of Medicine and his team evaluated over 16 years of records from those in the unselected representative patient population and found a modest, but statistically significant, improvement in overall survival rates. Specifically, one-year overall survival increased from 13.2 percent to 19.4 percent. Additionally, two-year overall survival increased from 4.5 percent to 7.8 percent........ http://www.lung-cancer-blog.com/blogs/permalinks/11-2009/identifying-high-risk-people-for-lung-cancer.html A study featured in the recent issue of the Journal of Thoracic Oncology confirms the success of a simple questionnaire designed to identify patients at high risk of lung cancer. Initiated in 2001, the current study confirmed 18 cases of cancer of the original 430 patients who qualified as high risk after completing a five-minute questionnaire........ http://www.lung-cancer-blog.com/blogs/permalinks/10-2009/genes-that-increases-risk-of-lung-cancer.html A recent study reported in the October 2009 issue of the Journal of Thoracic Oncology determined that variations of specific genetic markers identified in prior research, or SNPs, may indicate a greater lung cancer risk in African Americans than in whites. The genes CHRNA3 and CHRNA5 may contribute to lung cancer risk due directly or through their association with nicotine dependence. Eventhough their presence is less frequent in African Americans, the risk for lung cancer appears to be greater when present........ http://www.lung-cancer-blog.com/blogs/permalinks/5-2009/women-more-vulnerable-to-tobacco-carcinogens.html Women appears to be more vulnerable than men to the cancer-causing effects of smoking tobacco, as per new results reported this week at the European Multidisciplinary Conference in Thoracic Oncology (EMCTO), Lugano, Switzerland. Swiss scientists studied 683 patients with lung cancer who were referred to a cancer centre in St Gallen between 2000 and 2005 and found women tended to be younger when they developed the cancer, despite having smoked on average significantly less than men........ http://www.lung-cancer-blog.com/blogs/permalinks/4-2009/racial-disparities-in-the-treatment-of-lung-cancer.html Black patients suffering from lung cancer are less likely to receive recommended chemotherapy and surgery than white patients with lung cancer, a disparity that shows no signs of lessening. That is the conclusion of a newly released study reported in the May 15, 2009 issue of CANCER, a peer-evaluated journal of the American Cancer Society. The study's findings indicate that efforts are needed to provide appropriate therapys for black patients and to educate them about the value of those therapys........ http://www.lung-cancer-blog.com/blogs/permalinks/1-2009/to-improve-lung-cancer-risk.html About 1100 people each year die in the UK from lung cancer correlation to indoor radon, but current government protection policies focus mainly on the small number of homes with high radon levels and neglect the 95% of radon related deaths caused by lower levels of radon, as per a research studypublished on bmj.com today........ http://www.lung-cancer-blog.com/blogs/permalinks/10-2008/tobacco-smuggling-is-killing-more-people.html Tobacco smuggling causes around 4,000 premature deaths a yearfour times the number of deaths caused by the use of all smuggled illegal drugs put togetherbut the UK government is not doing enough to tackle the problem, claim experts on bmj.com today. Professor Robert West from the Cancer Research UK Health Behaviour Research Centre and his colleagues argue that more smokers would quit if cigarettes cost more, but at around half the price, smuggled tobacco is keeping the prices down........ http://www.lung-cancer-blog.com/blogs/permalinks/9-2008/pazopanib-shrinks-lung-cancers-before-surgery.html Pazopanib, a new oral angiogenesis inhibitor, has demonstrated interesting activity in difficult to treat non-small-cell lung cancer, US researchers report. In a phase II trial, 30 out of 35 patients treated with preoperative pazopanib for a minimum of two weeks saw their tumor size shrink by up to 85%........ http://www.lung-cancer-blog.com/blogs/permalinks/7-2008/cigarette-menthol-content.html Menthol cigarette brands have been rising in popularity with adolescents, and the highest use has been among younger, newer smokers. Scientists at Harvard School of Public Health (HSPH) explored tobacco industry manipulation of menthol levels in specific brands and found a deliberate strategy to recruit and addict young smokers by adjusting menthol to create a milder experience for the first time smoker. Menthol masks the harshness and irritation of cigarettes, allowing delivery of an effective dose of nicotine, the addictive chemical in cigarettes. These milder products were then marketed to the youngest potential consumers........ http://www.lung-cancer-blog.com/blogs/permalinks/7-2008/perceived-access-to-cigarettes.html Washington, DC Kids who see cigarettes as easily accessible are more likely to end up as regular smokers, especially if they have friends who smoke, as per a new report reported in the current issue of Annals of Family Medicine The study, funded by the Substance Abuse Policy Research Program (SAPRP) of the Robert Wood Johnson Foundation, could be valuable to smoking intervention efforts by allowing health professionals to identify and target high-risk children........ http://www.lung-cancer-blog.com/blogs/permalinks/5-2008/genetic-mutation-and-risk-of-lung-cancer.html Carriers of a common genetic disorder previously associated with lung disease may have a 70-percent to 100-percent increased risk of lung cancer, as per a report in the May 26 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. The disorder, alpha1-antitrypsin deficiency (1ATD), is one of the most common genetic conditions affecting the U.S. population and particularly those of European descent, as per background information in the article. Individuals with two copies of the associated genetic mutation often develop emphysema at an early age. However, 1ATD carriersthose with only one copy of the mutated genedo not normally have severe diseases correlation to 1ATD and may not be aware of their status. However, they may be more vulnerable to cancer-causing tobacco smoke than non-carriers........ http://www.lung-cancer-blog.com/blogs/permalinks/4-2008/researchers-id-gene-linked-to-lung-cancer.html Scientists at Johns Hopkins, as part of a large, multi-institutional study, have found one gene variant that is associated with an increased risk of lung cancer. The study would be reported in the April 3 issue of Nature Genetics. The research team collected DNA from 1,154 smokers who have lung cancer and 1,137 smokers without lung cancer. Each DNA sample was analyzed at more than 300,000 points, looking for variationsknown as single nucleotide polymorphisms, or SNPs for shortbetween those with cancer and those without. They then analyzed the top 10 SNPs in an additional 5,075 DNA samples from smokers with and without lung cancer........ http://www.lung-cancer-blog.com/blogs/permalinks/4-2008/new-method-to-test-for-lung-cancer.html Scientists from Boston University School of Medicine have developed a new clinicogenomic model to accurately test for lung cancer. The model combines a specific gene expression for lung cancer as well as clinical risk factors. These findings currently appear on-line in the journal Cancer Prevention Research........ http://www.lung-cancer-blog.com/blogs/permalinks/3-2008/cannabis-based-medicines-may-help-smokers-to-quit.html Smokers trying to quit in the future could do it with the help of cannabis based medicines, as per research from The University of Nottingham. Teams of pharmacologists, studying the cannabis-like compounds which exist naturally in our bodies (endocannabinoids), are exploring the potential for medical therapy. This includes treating conditions as diverse as obesity, diabetes, depression and addiction to substances like nicotine........